Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival
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منابع مشابه
Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells.
Vitamin D Receptor (VDR) is expressed in both animal and human ovarian tissue, however, the role of vitamin D in human ovarian steroidogenesis is unknown. Cultured human ovarian cells were incubated in tissue culture medium supplemented with appropriate substrates, with or without 50 pM-150 pM or 50 nM-150 nM of 1,25-(OH)2D3, and in the presence or absence of insulin. Progesterone, testosterone...
متن کاملInsulin-like growth factor binding protein 1 (IGFBP-1) in vaginal fluid in pregnancy.
OBJECTIVE To examine vaginal insulin-like growth factor binding protein 1 (IGFBP-1) as a marker of preterm delivery, amniotic fluid leakage or vaginal infection. MATERIALS AND METHODS The material consisted of a nested case-control study (67 with idiopathic preterm delivery and 406 randomly selected women with term deliveries) from a prospective cohort of 2,846 women. RESULTS Vaginal npIGFB...
متن کاملPhysiological differences in insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation in IGFBP-1 transgenic mice.
Insulin-like growth factor binding protein (IGFBP)-1 has been shown to alter cellular responses to insulin-like growth factor 1 (IGF-1). Human IGFBP-1 undergoes serine phosphorylation, and this enhances both its affinity for IGF-1 by six- to eightfold and its capacity to inhibit IGF-1 actions. To investigate the physiological role of IGFBP-1 in vivo, transgenic mice have been generated using ei...
متن کاملInsulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility.
The breast cancer malignant phenotype is regulated by steroid hormones and peptide growth factors. We have shown previously that insulin-like growth factor-I (IGF-I) stimulates cell motility in a metastatic cell line, MDA-231BO. In this study, we show that neutralization of IGF action by a type I IGF receptor (IGFR1) blocking antibody or neutralization of IGF-I by IGFBP-1 reduced cell motility....
متن کاملDifferential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy.
The insulin-like growth factors and their binding proteins are important for placental and foetal growth. In this study, we have investigated the presence of proteolytic activity directed against insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy. In addition, the effect of protease activity on IGFBP-1 immunoreactivity and IGF binding was characterised. 125I-IGFBP-1 was incubat...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2011
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2011.357